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Transient hiccups after posteroventral pallidotomy for Parkinson’s disease
  1. R M A DE BIE,
  2. J D SPEELMAN
  1. Department of Neurology
  2. Department of Neurosurgery, Academic Medical Center, University of Amsterdam, The Netherlands
  1. Dr R M A de Bie, Department of Neurology, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands. Telephone 0031 20 566 3856; fax 0031 20 679 1438; email R.M.deBie{at}amc.uva.nl
  1. P R SCHUURMAN,
  2. D A BOSCH
  1. Department of Neurology
  2. Department of Neurosurgery, Academic Medical Center, University of Amsterdam, The Netherlands
  1. Dr R M A de Bie, Department of Neurology, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands. Telephone 0031 20 566 3856; fax 0031 20 679 1438; email R.M.deBie{at}amc.uva.nl

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Hiccup is defined as an abrupt intermittent, involuntary, contraction of the diaphragmatic and external (inspiratory) intercostal muscles, with inhibition of expiratory intercostal activity. This results in a sudden inspiration, abruptly opposed by closure of the glottis.1 Hiccup may result from various structural or functional disorders of the medulla, the afferent or efferent nerves to the respiratory muscles, and the gastrointestinal tract.2 3 Newson Davis performed a study of hiccup with electrophysiological techniques and concluded that hiccup is served by a supraspinal mechanism distinct from that generating rhythmic breathing.3 The principal site of interaction of the hiccup discharge with other descending drives to the respiratory motoneuron is at the spinal level. Neurogenic hiccup is particularly associated with structural lesions of the medulla …

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