Autosomal dominant burning feet syndrome
- Florian Stögbauera,
- Peter Younga,
- Gregor Kuhlenbäumera,d,
- Reinhard Kiefera,
- Vincent Timmermand,
- E Bernd Ringelsteina,
- Jian-Feng Wangb,
- J Michael Schröderb,
- Christine Van Broeckhovend,
- Joachim Weisc
- aDepartment of Neurology, University of Münster, Germany, bDepartment of Neuropathology, University of Aachen, Germany, cInstitute of Pathology, University of Bern, Switzerland, dNeurogenetics Laboratory, Flanders Interuniversity Institute for Biotechnology (VIB), Born Bunge Foundation (BBS), Department of Biochemistry, University of Antwerp (UIA), Belgium
- Dr Florian Stögbauer, Department of Neurology, University of Münster, Albert Schweitzer Strasse 33, D-48129 Münster, Germany. Telephone 0049 251 8348178; fax 0049 251 8348181; email stogbau{at}uni-muenster.de
- Received 29 May 1998
- Revised 27 January 1999
- Accepted 4 February 1999
Abstract
Familial burning feet syndrome inherited as an autosomal dominant trait has been described in only one family. Due to an associated sensory neuropathy the autosomal dominant burning feet syndrome was suggested to represent a variant form of hereditary sensory and autonomic neuropathy type I (HSAN I). Clinical, histopathological, and molecular genetic studies were performed in a large German kindred with autosomal dominant burning feet syndrome. The autosomal dominant burning feet syndrome was associated with a neuropathy predominantly affecting small unmyelinated nerve fibres. Linkage to the HSAN I locus on chromosome 9q22 and to the Charcot-Marie-Tooth disease type 2B (CMT 2B) locus on chromosome 3q13-q22 was excluded. The autosomal dominant burning feet syndrome is neither allelic to HSAN I nor to CMT 2B and thus represents a distinct genetic entity.
