Spontaneous intralesional haemorrhage in dysembryoplastic neuroepithelial tumours: a series of five cases
- Maria Thoma,
- Beatriz Gomez-Ansonb,
- Tamas Revesza,
- William Harknessc,
- Ciaran J O’Briend,
- Rupert Kett-Whitee,
- E Wyn Jonesf,
- John Stevensb,
- Francesco Scaravillia
- aDepartment of Neuropathology, bDepartment of Neuroradiology, cDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, dDepartment of Histopathology, eDepartment of Neurosurgery, fDepartment of Neuroradiology, Morriston Hospital, Swansea, UK
- Dr Maria Thom, Department of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. Telephone 0044 171 837 3611; fax 0044 171 916 9546.
- Received 17 March 1998
- Revised 15 October 1998
- Accepted 29 October 1998
Abstract
Five patients with dysembryoplastic neuroepithelial tumour (DNT) showing extensive secondary haemorrhage, a finding not previously associated with these neoplasms, are described. The clinical presentations, neuroimaging findings, and histopathological features of these patients are reviewed. One patient, a previously asymptomatic 12 year old girl, presented with an acute intracerebral haemorrhage into a DNT. A further four young adults with histories of intractable partial and generalised seizures dating from childhood showed significant chronic haemorrhages within DNT, the MRI appearances in one patient giving a false impression of a cavernoma. Histopathology disclosed vascular abnormalities within these tumours which, together with other factors discussed, may have predisposed these tumours to haemorrhage.
