Clinical and magnetic resonance imaging heterogeneity in multiple sclerosis
All clinicians who see patients with multiple sclerosis will be profoundly aware of the highly variable and unpredictable clinical course. Surprisingly, the mechanisms which account for clinical heterogeneity are poorly understood. A clearer understanding of these mechanisms is desirable, as it may open the way to new and more effective therapeutic strategies.
It is likely that pathological heterogeneity underlies the different clinical courses. A postmortem study comparing primary and secondary progressive multiple sclerosis has shown significantly less inflammation in the primary progressive group,1 a …
