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False negative polymerase chain reaction on cerebrospinal fluid samples in tuberculous meningitis
  1. D M GASCOYNE-BINZI,
  2. P M HAWKEY
  1. Department of Microbiology, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK
  1. Dr D M Gascoyne-Binzi, Department of Microbiology, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, UK.

https://doi.org/10.1136/jnnp.67.2.250

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    There have been few studies in the literature concerned solely with the use of the polymerase chain reaction (PCR) to identifyMycobacterium tuberculosis DNA directly from CSF.1-4 These studies suggest that in some cases, PCR may be more sensitive than culture; however, in the largest study, performed …

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