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  • Association between butyrylcholinesterase K variant and the Alzheimer type neuropathological changes in apolipoprotein E ε4 carriers older than 75 years

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Association between butyrylcholinesterase K variant and the Alzheimer type neuropathological changes in apolipoprotein E ε4 carriers older than 75 years
  1. N SODEYAMA,
  2. M YAMADA,
  3. H MIZUSAWA
  1. Department of Neurology
  2. Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
  3. Department of Pathology, Yokufukai Geriatric Hospital, Tokyo, Japan
  4. Department of Neuropathology, Tokyo Institute of Psychiatry, Tokyo, Japan
  1. Dr Masahito Yamada, Department of Neurology, Tokyo Medical and Dental University, Yushima 1–5–45, Bunkyo-ku, Tokyo 113–8519, Japan. Telephone 0081 3 5803 5234; fax 0081 3 5803 0169; email m-amada.nuro{at}med.tmd.ac.jp
  1. Y ITOH,
  2. E OTOMO
  1. Department of Neurology
  2. Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
  3. Department of Pathology, Yokufukai Geriatric Hospital, Tokyo, Japan
  4. Department of Neuropathology, Tokyo Institute of Psychiatry, Tokyo, Japan
  1. Dr Masahito Yamada, Department of Neurology, Tokyo Medical and Dental University, Yushima 1–5–45, Bunkyo-ku, Tokyo 113–8519, Japan. Telephone 0081 3 5803 5234; fax 0081 3 5803 0169; email m-amada.nuro{at}med.tmd.ac.jp
  1. N SUEMATSU
  1. Department of Neurology
  2. Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
  3. Department of Pathology, Yokufukai Geriatric Hospital, Tokyo, Japan
  4. Department of Neuropathology, Tokyo Institute of Psychiatry, Tokyo, Japan
  1. Dr Masahito Yamada, Department of Neurology, Tokyo Medical and Dental University, Yushima 1–5–45, Bunkyo-ku, Tokyo 113–8519, Japan. Telephone 0081 3 5803 5234; fax 0081 3 5803 0169; email m-amada.nuro{at}med.tmd.ac.jp
  1. M MATSUSHITA
  1. Department of Neurology
  2. Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
  3. Department of Pathology, Yokufukai Geriatric Hospital, Tokyo, Japan
  4. Department of Neuropathology, Tokyo Institute of Psychiatry, Tokyo, Japan
  1. Dr Masahito Yamada, Department of Neurology, Tokyo Medical and Dental University, Yushima 1–5–45, Bunkyo-ku, Tokyo 113–8519, Japan. Telephone 0081 3 5803 5234; fax 0081 3 5803 0169; email m-amada.nuro{at}med.tmd.ac.jp

https://doi.org/10.1136/jnnp.67.5.693

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    Apolipoprotein E (ApoE) ε4 has a strong influence on the development of sporadic Alzheimer’s disease in many ethnic populations. However, ApoE ε4 is neither necessary nor sufficient for the development of Alzheimer’s disease, suggesting that other genes increase the risk of Alzheimer’s disease. One such new candidate is the butyrylcholinesterase (BChE) gene (BCHE).1 BChE is associated with senile plaques (SPs) and neurofibrillary tangles (NFTs). Lehmannet al recently reported that the K variant of BCHE (BCHE-K) was associated with the development of Alzheimer’s disease, especially in ApoE ε4 carriers older than 75 years.1 A possible mechanism as to how BCHE-K is related to Alzheimer’s disease under the influence of ApoE ε4 is the acceleration of Alzheimer type neuropathological changes. IfBCHE-K has an effect on the development of Alzheimer’s disease in ApoE ε4 carriers, the formation of Alzheimer type neuropathological changes may be accelerated byBCHE-K in the ApoE ε4 carriers.

    We have examined genotypes of BCHE and ApoE, and densities of the senile plaques (SPs), with dystrophic neurites (NPs), and neurofibrillary tangles NFTs in the brains from 51 patients with Alzheimer’s disease and 90 non-demented subjects from a postmortem series of Japanese. Clinical and postmortem diagnosis of Alzheimer’s disease was carried out as described previously.2 The densities of Alzheimer type neuropathological changes were quantified by averaging the counts of those in the hippocampus and superior temporal gyrus. Genotypes ofBCHE …

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