BCL-2 Family protein expression in initial and recurrent glioblastomas: modulation by radiochemotherapy

Table 3

Protein expression: median cumulative scores, quartiles (25% and 75% percentiles), and p values

		BCL-2				BCL-X			BAX		MCL-1
		Initial	Recurrence			Initial	Recurrence		Initial	Recurrence	Initial	Recurrence
Whole group (n=37)	15	19		20	25		14	11	10	11
Quartiles	13–16	16–22		15–23	23–29		11–15	10–12	10–11	10–13
p Value	< 0.0001			< 0.0001			< 0.0001		0.0395
Radiochemoth (n=15)	14	19		18	25		12	11	10	11
Quartiles	12.5–15	17.5–20.5		12–24	22–28		10.5–16	10–11	10–11.5	10–13
p Value	0.0012			0.0031			0.0122		0.0977
Radiotherapy (n=15)	15	17		20	22		14	12	10	11
Quartiles	13–18	15.5–22.5		15–23	17.5–30		11–14	10.5–13	10–11	10.5–13
p Value	0.0125			0.081			0.2402		0.0186
Untreated (n=7)	15	22		22	29		15	12	11.00	11.00
Quartiles	14–16	14–26		19–24.5	24.5–29.5		11.5–16.5	12–15	11–15.5	11–13.5
p Value	0.0781			0.3125			0.4375		0.6250

According to the Bonferroni method, only p values <0.017 are presumed to be significant at the 0.05 level in the subgroups.

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BCL-2 Family protein expression in initial and recurrent glioblastomas: modulation by radiochemotherapy

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