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Abnormal calcium phosphate metabolism has not previously been associated with Asperger's syndrome, a form of pervasive developmental disorder. Nor have symmetric calcifications of the basal ganglia, dentate nuclei and cortex, or Fahr's disease1—whether idiopathic or associated with hypoparathyroidism—previously been associated with this handicap. We present the case of a 24 year old man with Asperger's syndrome, primary hypoparathyroidism, and multifocal brain calcifications.
According to medical history, the patient's mother had received weekly injections of Depoprovera during pregnancy. A single child born after a normal term delivery, he underwent surgery for an inguinal hernia at 3 weeks. Developmental milestones were only moderately delayed. At 9 months, he rolled instead of crawling. He walked at 15 months, spoke at 2 years with poor articulation, and still speaks in short, unelaborated sentences. His social and language development lagged in grade school and he occasionally got into fights. In late adolescence, antisocial behaviour took the form of …