Article Text
Correspondence
Nitric oxide in acute ischaemic stroke
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The pivotal role of nitric oxide (NO) in cerebral ischaemia has been elegantly highlighted in the recent editorial by O'Mahony and Kendall.1 Although studies of neuroprotective agents have been largely disappointing, pharmacological manipulation of NO may represent a novel means of protecting the brain from ischaemic insult. One area not discussed in this editorial is the neuroprotective effect of 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors or “statins” in cerebral ischaemia. Preliminary studies have shown that statins modulate brain nitric …