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J Neurol Neurosurg Psychiatry 2000;68:275-276 doi:10.1136/jnnp.68.3.275
  • Editorial commentary

Corticobasal degeneration

  1. A KERTESZ
  1. Department of Clinical Neurological Sciences, University of Western Ontario, St Joseph's Hospital, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
  2. kertesz@lri.stjosephs.london.on.ca

      Corticobasal ganglionic degeneration (CBGD) or corticobasal degeneration (CBD) is a pathological diagnosis in search of a nosological niche. It was originally described as corticodentatonigral degeneration by Rebeizet al,1 who recognised its relation to Pick's disease because of the focal cortical atrophy and the ballooned neurons (Pick cells). The clinical syndrome was first characterised by a combination of unilateral extrapyramidal signs and prominent apraxia, usually diagnosed in movement disorder clinics. …

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