Recovery from optic neuritis is associated with a change in the distribution of cerebral response to visual stimulation: a functional magnetic resonance imaging study
- David J Werringa,
- Edward T Bullmoreb,
- Ahmed T Toosya,
- David H Millera,
- Gareth J Barkera,
- David G MacManusa,
- Michael J Brammerb,
- Vincent P Giampietrob,
- Adriana Brusaa,
- Peter A Brexa,
- Ivan F Moseleya,
- Gordon T Planta,
- W Ian McDonalda,
- Alan J Thompsona
- aNMR Research Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK, bBrain Image Analysis Unit, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
- Professor AJ Thompson, Institute of Neurology, Queen Square, London WC1N 3BG, UK email A.Thompson{at}ion.ucl.ac.uk
- Received 19 May 1999
- Revised 23 November 1999
- Accepted 3 December 1999
Abstract
OBJECTIVES Recovery to normal or near normal visual acuity is usual after acute demyelinating optic neuritis, despite the frequent persistence of conduction abnormalities as evidenced by the visual evoked potential (VEP). This raises the possibility that cortical adaptation to a persistently abnormal input contributes to the recovery process. The objective of this study was to investigate the pattern of cerebral response to a simple visual stimulus in recovered patients in comparison to normal subjects.
METHODS Functional magnetic resonance imaging (fMRI) was used to study the brain activation pattern induced by a periodic monocular 8Hz photic stimulus in seven patients who had recovered from a single episode of acute unilateral optic neuritis, and in seven normal controls. VEPs and structural optic nerve MRI were performed on patients.
RESULTS Stimulation of either eye in controls activated only the occipital visual cortex. However, in patients, stimulation of the recovered eye also induced extensive activation in other areas including the insula-claustrum, lateral temporal and posterior parietal cortices, and thalamus; stimulation of the clinically unaffected eye activated visual cortex and right insula-claustrum only. The volume of extraoccipital activation in patients was strongly correlated with VEP latency (r=0.71, p=0.005).
CONCLUSIONS The extraoccipital areas that were activated in patients all have extensive visual connections, and some have been proposed as sites of multimodal sensory integration. The results indicate a functional reorganisation of the cerebral response to simple visual stimuli after optic neuritis that may represent an adaptive response to a persistently abnormal input. Whether this is a necessary part of the recovery process remains to be determined.
