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J Neurol Neurosurg Psychiatry 2000;69:148-149 doi:10.1136/jnnp.69.2.148
  • Editorial commentary

Cerebral dysfunction and psychotic symptoms in Alzheimer's disease

  1. B TOONE
  1. Department of Psychiatry, King's College Hospital, Denmark Hill, London SE5 9RS, UK

      Psychotic phenomena are far from uncommon in Alzheimer's disease; delusions are present in up to three quarters of patients, hallucinations in up to a half. They appear as the disease progresses into its middle phase and are associated with cognitive decline. A better understanding of the psychopathogenetic mechanisms through which psychotic experience is mediated would have implications that would extend well beyond Alzheimer's disease; in this respect it could provide a neurological model for the so called functional psychoses. Some studies …

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