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J Neurol Neurosurg Psychiatry 2000;69:512-515 doi:10.1136/jnnp.69.4.512
  • Short report

Chorea resulting from paraneoplastic striatal encephalitis

  1. T Tania,
  2. Y-S Piaoc,
  3. S Moria,
  4. N Ishiharab,
  5. K Tanakad,
  6. K Wakabayashie,
  7. H Takahashic
  1. aDepartment of Neurology, Saiseikai Niigata 2nd Hospital, Niigata, Japan, bDepartment of Pathology, cDepartment of Pathology, Brain Research Institute, Niigata University, 1 Asahimachi, Niigata 951–8585, Japan, dDepartment of Neurology, eBrain Disease Research Center
  1. Dr Hitoshi Takahashihitoshi{at}bri.niigata-u.ac.jp
  • Received 12 October 1999
  • Revised 21 May 2000
  • Accepted 2 June 2000

Abstract

A 73 year old man presented with progressive choreic movement and dementia. An antineuronal antibody that recognised a 68 kDa band on a western blot was found in the patient's serum; this antibody immunolabelled neuronal somata in rat brain. Postmortem examination showed a small cell lung cancer and severe neuronal loss with lymphocytic infiltration in the striatum that was more severe in the caudate head. This is thought to be the first pathologically proved case of paraneoplastic chorea with striatal encephalitis.

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