Article Text

PDF

Sexuality in young patients with Parkinson's disease: a population based comparison with healthy controls
  1. Helfried Jacobs,
  2. Alexandra Vieregge,
  3. Peter Vieregge
  1. Department of Neurology, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany
  1. Professor Peter Viereggevieregge_p{at}neuro.mu-luebeck.de

Abstract

Answers from a multiple choice questionnaire on the opinions about public sexual attitudes, on emotion from personal sexual practice, on personal sexual function, and on general health perception were compared between 121 patients with Parkinson's disease (mean age 45 years) and 126 age and sex matched community derived controls. Patients were more dissatisfied with their present sexual functioning and relationship, and perceived their general health as poorer than the controls, whereas opinions about public sexual attitudes were only marginally different. No differences were found for sexual function. Further analysis showed that the perception of sexual functioning and general health in younger patients with Parkinson's disease is considerably influenced by depression and state of unemployment.

  • Parkinson's disease
  • sexuality
  • depression
  • quality of life

Statistics from Altmetric.com

Until today, it is unclear whether patients with Parkinson's disease differ in sexuality from healthy people of similar age.1-5 One reason for this ambiguity is that most earlier studies have methodological restrictions (inclusion of exclusively men,4 women,5 spouses as controls2 3). We therefore studied sexuality in a group of younger patients with Parkinson's disease and compared the findings with a community derived matched control group of healthy people.

Materials and methods

Patients with definite Parkinson's disease and younger than 51 years were recruited from membership lists of the “German Parkinson's Association”, a self support organisation of patients with Parkinson's disease. Also, patient lists of physicians were used whom the authors knew for their interest in care of patients with Parkinson's disease. A letter explaining the study design was sent to the patients by the lay organisation or by the respective physician. Age (±3 years) and sex matched controls were randomly drawn from the community registry of the City of Lübeck. For each patient, four healthy people were asked by letter to participate. If the control did not respond to the first letter, a reminding letter was sent 2 weeks later. In cases of no response, a third and final letter, again sent 2 weeks later, asked for reasons of non-participation. Participants were requested to answer to the study centre by letter or phone. On this occasion, they could ask questions about the study. For participation, all subjects had to give their written informed consent. The study was approved by the medical ethics committee of the Medical University of Lübeck and the data protection specialist of the Province of Schleswig-Holstein.

During the visit the physician investigator (HJ) examined the patients personally. He reviewed the medical records of treating physicians. Parkinson's disease was defined according to the United Kingdom Parkinson's Disease Society brain bank criteria.6 In all patients the motor part of the unified Parkinson's disease rating scale7 and the Hoehn and Yahr score8 were determined. Patients and controls then had a structured interview about disease variables and sociodemographic data that was followed by a multiple choice questionnaire about sexuality.9 Arranged in random order, 33 items covered opinions about public sexual attitudes (eight questions), emotion from personal sexual practice (18 questions), intercourse frequency as a measure of sexual function (four questions), and general health perception (three questions). Participants had to fill in the questionnaire while the investigator was present. To assess educational influences the short form of the Wechsler adult intelligence scale10 (subtests information, similarities, picture completion, and block design) was applied. Depressive mood was assessed with the paranoid-depression scale,11 a standardised German questionnaire listing 43 statements that in random order cover feelings and thoughts of paranoia, depression, and denial of psychiatric illness. The degree of agreement to every item has to be graded by the subject into one of four categories (applies definitely; applies mostly; applies somewhat; does not apply). Raw scores were transformed into sex corrected T values normalised for German adults. T Values above 56.3 (women) and 56.8 (men) indicate substantial depression. χ2 Analysis and Student's t test were performed using the statistical package for the social sciences (SPSS-PC). Statistical significance was assumed at p<0.05. Stratified samples were analysed by 2*k comparison of cross tables.12 Here, statistical significance was assumed at p<0.01.

Results

Two hundred and eighty patient members of the lay organisation were approached, another 13 patients were asked during local gatherings of the organisation. Ninety five patients were addressed from physician lists. Of these 388 patients, 163 agreed to participate (121 association members (43%); 42 patients from physician lists (44%)). Sixteen patients refused (all association members), 209 did not answer (155 association members (55%); 54 patients from physician lists (56%)). Thirty four patients were excluded because they were located too far away. Eight patients were excluded because they did not fulfil the study criteria, leaving 121 patients who completed the questionnaire. Of the 508 controls approached, 128 (25%) agreed to participate, 194 (38%) refused, and 186 (37%) never responded. Two controls withdrew during the investigation, leaving 126 controls who completed the questionnaire.

Sociodemographic data are shown in table 1. All subjects reported to presently live in a heterosexual partnership. Significantly more patients than controls were currently unemployed and had depression. Patients more often disagreed about the present attitude of most people towards sexuality (table 2). Patients also disapproved of homosexuality more often. More patients than controls indicated dissatisfaction with their current sexual life. Dissatisfied patients (T value of depression score 66.9 (SD 9.1)) showed more depression than satisfied patients (T value 59.7 (SD 8.4); p<0.01). Also, dissatisfied patients were more often men than women (36% v 20%; p<0.01). No such differences were seen among the control persons. Depressed and unemployed patients were more often dissatisfied with their present sexual relationship, less able to enjoy a small flirtation, and felt lonely more often (p<0.01, each). Frequency of intercourse was not different between groups. Patients were more often dissatisfied with their life so far, felt older than their present age, and perceived their current health as worse than the controls. Perceived current health status was worse in patients with depression and unemployment (p<0.01 each). No other demographic or disease variable was related to the answer pattern.

Table 1

Disease indices, sociodemographic variables, and neuropsychological test results in 121 patients with Parkinson's disease and 126 controls

Table 2

Opinions about public attitudes towards sexuality, emotion from own sexual practice, personal sexual function, and general health perception in 121 patients with Parkinson's disease and 126 controls. For each category, the numbers of responses from patients and controls (x/y) are given

Discussion

Opinions about public sexual attitudes and the emotion from personal sexual practice were only slightly different between younger patients with Parkinson's disease and healthy controls living in the community. By contrast with previous data, sexual dissatisfaction did not increase with duration or severity of Parkinson's disease in our patients.1 On the measure of change in sexuality we did not propose a time frame: respondents were simply asked whether or not “sexuality is as satisfying now as in the past”. However, responses on frequency of intercourse did not differ for either “10 years ago” or “currently”. It seems unlikely, therefore, that the lack of a defined time frame for measuring a change in sexuality has distorted our results. Our data underline that sexual problems in Parkinson's disease may particularly arise in couples where the patient is male2: Only in the patient group were male but not female respondents dissatisfied with their current sexual relationship. We were able to substantiate the earlier assumption2 that the male bias in distribution of sexual difficulties is related to state of employment. In patients with Parkinson's disease, unemployment seems as important as depression in determining the answer pattern about satisfaction with sexuality and personal life as yet. Both factors also relate to the worse perception of general health in the patients.

Our study has strengths and limitations. Firstly, all patients were examined by always the same investigator according to defined criteria and to an established procedure. By cross checking patient diagnoses and clinical records, we were able to obtain a high level of consistency for data collection and diagnosis of Parkinson's disease. Secondly, as a result of our case ascertainment, patients with mild disease may be underrepresented, whereas more severely ill patients—that is, patients with a longer disease duration and more depression—may be overrepresented. Also, depressed patients with a chronic condition are likely to care more for their health than non-depressed patients.13 They are, therefore, more likely to participate in studies such as the present one. The overall proportion of depressive patients was high compared with earlier studies about sexuality in Parkinson's disease.1 2 4 5It was also higher than in a recent population study on depression in Parkinson's disease.14

Thirdly, three quarters of our patients were members of a lay organisation for Parkinson's disease. Thus, selection bias towards the well informed may have been introduced. However, our results were remarkably independent of educational level. Fourthly, the rates of participation in patients and controls were low. But with a proportion of 81% of regular employment and almost equally distributed levels of education, our control group appeared as a representative sample of the normal population. Fifthly, self selection cannot be ruled out. However, all people taking part in the entire study on sociodemographic variables and risk factors of Parkinson's disease answered the questionnaire about sexuality. This questionnaire was not explicitly announced as part of the study during proband recruitment. Therefore, a selection bias for participation in only this questionnaire seemed to be unlikely. Sixthly, the absolute numbers in some questionnaire responses were admittedly small. Conclusions from our results should therefore be drawn cautiously. Nevertheless, our data appeared consistent throughout.

Taken together, our study confirms that depression in patients with somatic disorders is more relevant to the subjective sense of dissatisfaction with their sexuality rather than physiological dysfunction15 16 and that depressive mood significantly influences the answer pattern in inquiries about sexuality in patients with Parkinson's disease. Unemployment as another determining factor points to complex mutual effects of psychosocial factors on sexuality in younger patients. Physicians should consider psychological rather than somatic intervention in younger patients with Parkinson's disease who are dissatisfied with their sexual life.

Acknowledgments

We thank many colleagues for their help in patient recruitment, and Dr L Wermuth for sending us the questionnaire from her earlier investigation. Partial financial support from the German Parkinson's Disease Association is kindly acknowledged.

References

View Abstract

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.