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Hyperhomocysteinaemia in Alzheimer's disease and expression of cell cycle markers in the brain
  1. ZS NAGY,
  2. M Z SMITH,
  3. M M ESIRI,
  4. L BARNETSON,
  5. A D SMITH
  1. OPTIMA, University Department of Pharmacology Mansfield Road, Oxford OX1 3QT, UK and Department of Neuropathology, Radcliffe Infirmary NHS Trust, Oxford OX2 6HE, UK
  1. david.smith{at}pharm.ox.ac.uk

https://doi.org/10.1136/jnnp.69.4.565

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    We report that moderately increased concentrations of serum total homocysteine in Alzheimer's disease are associated with the expression of cyclin E (a marker of entry into the cell division cycle) in neurons of the hippocampus. Aberrant entry of neurons into the cell cycle might be an early step in the pathological process.

    Expression of proteins related to the control of the cell division cycle has been found in the nuclei of neurons in the cerebral cortex in Alzheimer's disease and it has been proposed that the expression of such proteins, in the absence of cell division, might lead to death of neurons by apoptosis or to the development of neurofibrillary pathology.1 If the aberrant expression of cell cycle markers is part of the pathological process, then it is important to identify possible factors that might trigger the entry of …

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