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Increased jugular bulb saturation is associated with poor outcome in traumatic brain injury

Abstract

The objective was to compare secondary insults, particularly decreases in jugular bulb oxyhaemoglobin saturation (SjO2), during intensive care in patients with “poor” and “good” outcomes 12 months after traumatic brain injury.

 A prospective observational study of patients' physiological data collected each minute from multimodality monitoring was carried out. Patients had duration of physiological insults quantified as a percentage of their validated monitoring time (once invalid data due to technical reasons were removed). Treatment protocols were designed to minimise secondary insults by maintaining intracranial pressure (ICP) less than 20 mm Hg, and cerebral perfusion pressure (CPP) greater than 70 mm Hg, with prompt correction of hypoxia and pyrexia. Twelve months after injury patients' neurological function was assessed using the Glasgow outcome scale (GOS). A poor outcome was defined as GOS 1 to 3 (group 1) and a good outcome as GOS 4 and 5 (group 2).

 Seventy five patients (64 male), median age of 34 years (range 15 to 70), were studied. At 12 months 33 patients had a poor outcome (group 1), and 42 a good outcome (group 2). Group 1 spent proportionately more time with SjO2 greater than 75% compared with group 2 (p<0.05), and more time with SjO2 below 54% (p<0.04). Group 1 patients also spent proportionately more time with CPP less than 70 mm Hg than group 2 (p<0.04). Patients in group 1 were older (p<0.04) and had a lower postresuscitation Glasgow coma score (p<0.002). There was no difference between the groups for ICP, injury severity score, peripheral pulse saturation, and pyrexia.

 This study confirms that secondary insults, including an increased SjO2, occur significantly more in patients with poor outcomes. More research into strategies to reduce the impact of secondary insults, including management of increased SjO2, is required.

  • head injury
  • jugular bulb venous oxygen saturation
  • cerebral oxygenation

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Traumatic brain injury has devastating consequences including severe brain damage and death, and affects predominantly young adults aged 15 to 35 years.1 No pharmaceutical progress has been made to improve the outcome for these patients. In the absence of a “magic bullet” current best practice recommendations aim to reduce secondary insults to the brain.2 Secondary brain injury from physiological insult is common after traumatic brain injury3 and is caused by hypoxia and hypotension, both of which are associated with poor outcomes.4 There is evidence to suggest that high intracranial pressure (ICP),5 low cerebral perfusion pressure (CPP) and low jugular bulb oxyhaemoglobin saturation (SjO2)6are also associated with a poor prognosis.

Evidence suggestive of ischaemic brain damage is commonly found in patients who die from traumatic brain injury7; thus, ischaemia may be the final common pathway of secondary insults in patients with fatal injuries. The SjO2 is a measure of global brain oxygen extraction (SjO2 varies directly with cerebral blood flow and indirectly with the cerebral metabolic rate for oxygen (CMRO2)). Over the past 15 years continuous measurement of SjO2 has become part of routine monitoring in many neurointensive care units.

This study reports on multimodality monitoring data, in particular SjO2, and their relation with neurological outcome in a cohort of patients with traumatic brain injury, and identifies where additional effort to reduce secondary insults may be appropriate.

Patients and methods

PATIENTS

Local ethics committee approval was obtained before the start of the study. Between June 1990 and May 1995 75 patients were recruited on the basis of requiring mechanical ventilation in the neurointensive care unit for management of traumatic brain injury. Patients were studied consecutively except where the number of patients concurrently in the unit exceeded the number of computers available to collect data.

Patients were managed using a protocol to minimise secondary insults. It included paralysis (as clinically indicated), mild hyperventilation to Pa CO2 of 4.5±0.5 kPa, sedation and analgesia using benzodiazepine and alfentanil, and ICP below 20 mm Hg using furosemide, mannitol, and more aggressive hyperventilation (keeping SjO2 within normal limits of 54% to 75%) as necessary. The CPP was maintained above 70 mm Hg with fluid and vasopressors (norepinephrine±dobutamine). The jugular bulb was cannulated using a well described technique8; a compliance test was performed to determine the jugular bulb which had the largest vascular territory, but if the compliance test was equitable (similar ICP reading for each side) the right jugular bulb was chosen. Catheter tip position was verified by lateral neck radiography (to lie above the disc space of C1 and C2) and the catheter marked externally so that the position could be checked regularly, including calibrations which were done every 12 hours. Inspired oxygen concentration, which influences SjO2, was kept to the minimum required to obtain a PaO2 of 10 mm Hg (and SpO2 of 94%) according to arterial blood gas sampling, which was done at least three times a day; all patients were therefore treated equally. Values for SjO2 outside normal limits were verified by first confirming the catheter tip position, then measuring a jugular bulb blood sample by oximetry (ILS Co-Oximeter 282). If SjO2 was confirmed to be less than 54% mechanical ventilation was manipulated causing Pa CO2 to increase, and CPP was optimised. No specific treatment protocol was instituted for SjO2 values exceeding 75% unless ICP was greater than 30 mm Hg or CPP less than 70 mm Hg for 5 minutes as described above.

CONTINUOUS PHYSIOLOGICAL MEASUREMENTS

Minute by minute physiological data were collated and analysed using purpose written software—the Edinburgh Monitor and Edinburgh Browser.9 Data included arterial blood pressure, central venous pressure (CVP), ICP, and CPP (mean arterial pressure minus ICP), SjO2, peripheral pulse oximetry, and core temperature. Physiological insults outside normal values have previously been documented3 and included ICP less than 20 mm Hg, CPP less than 70 mm Hg, SjO2 less than 54% or greater than 75%, peripheral pulse saturation less than 92%, and pyrexia greater than 380C. An insult was registered when the measurement was continuously outside normal limits for a minimum of 5 minutes. Conversely, the termination of an insult was registered when the measurement was continuously within normal limits for 5 minutes. Data collection began at the time of admission to the neurointensive care unit (or as soon as practically possible within 24 hours) and ended either at death (determined in the four patients who were brain stem dead as the time of first set of tests), or when there was no longer a clinical requirement for each particular monitor. The ICP was measured with a Camino fibreoptic monitor (Camino, San Diego, CA, USA) placed in the brain parenchyma. The SjO2 was measured continuously with a 40 cm Shaw Opticath and Oximetrix 3 computer with the Oximetrix 3 system (Abbott Critical Care Systems, Chicago, IL, USA). The system and placement technique for the SjO2 catheter has previously been described.8

The physiological data were validated by an experienced clinical researcher who eliminated erroneous measurements3—for example, arterial pressures recorded during line sampling and SjO2 values recorded during poor signal quality. The Oximetrix 3 system lends itself particularly well to this validation process as it can be assessed objectively off line using the hard copy signal quality indicator that it produces. Data remaining (56%) were deemed “validated monitoring time” data. To make statistical comparisons between patient outcome groups the total duration of insults was expressed as a percentage of validated monitoring time for each variable, for each patient.

ASSESSMENT OF NEUROLOGICAL OUTCOME

Information was gathered 12 months after injury from hospital notes and questionnaire responses of relatives and the patient's general practitioner. A blinded researcher then determined the quality of outcome according to the Glasgow outcome scale (GOS).10Those judged to have a “poor” outcome with GOS 1 to 3 (group 1), were dead, vegetative, or severely disabled. Those with a “good” outcome, GOS 4 and 5 (group 2), were moderately disabled or had made a good recovery.

STATISTICAL METHODS

Mann-Whitney U tests were used to compare data (all non-gaussian) from both patient groups using computer software (Minitab Inc Release 11, State College, PA 16801–3008, USA). Significance was assumed at p<0.05.

Results

Seventy five patients (65 male) were studied. Follow up at 12 months showed that 33 had poor outcomes (group 1), including 16 deaths, and 42 had good outcomes (group 2). Their median age was 34 (range 15–70) years, group 1 being older (38 (range 15–69)) than group 2 (31 (range 16–70); p=0.04). After initial resuscitation the median Glasgow coma scale (GCS) was 4 (range 3–11) in group 1 and 7 (range 3–12) in group 2 (p<0.002) associated with a median injury severity score in group 1 of 21 (range 13–54) and in group 2 of 22 (range 9–34) (p=0.4). The causes of traumatic brain injury are shown in the table.

Causes of traumatic brain injury

The total duration of validated monitoring time of SjO2 in group 1 was 123 135 minutes (median 2698 (range 49 to 19 158)) and in group 2 it was 141 620 minutes (2262 (range 681–11 300)) (p>0.05). Physiological secondary insults, as a proportion of validated monitoring time, differed significantly between the groups. A larger proportion of patients in group 1 had a duration of SjO2greater than 75% (p<0.05) and SjO2 less than 54% (p<0.04) (figure). When actual validated time (in minutes) spent at insult values was analysed the difference between the groups for increased and decreased SjO2 became even more significant. There was no difference in the proportion of those patients with increased SjO2 in group 1 between those who died (GOS 1) and those surviving with poor outcomes (GOS 2 and 3), but those who died had a greater proportion of decreased SjO2 (p<0.003). Group 1 had a greater proportion of validated monitoring time with CPP less than 70 mm Hg compared with group 2 (p<0.04). There were no significant differences between the two groups for ICP greater than 20 mm Hg, pulse oximetry less than 92%, or temperature greater than 380C (two patients in each group did not have core temperature recorded).

Cumulative histograms of SjO2 values monitored in patients with traumatic brain injury in a neurointensive care unit. The y axis represents the percentage of good monitoring time and the x axis SjO2 values from 20%-100%. (A) 33 patients with 12 month Glasgow outcome scores (GOS) 1 to 3; total good monitoring time was 12 3135 minutes (median 2698). (B) 43 patients with 12 month GOS 4 or 5; total good monitoring time was 141 620 minutes (median 2262) (p>0.05). Comparing SjO2 values outside normal limits, patients with GOS 1–3 had more proportional validated monitoring time at low (<54%) (p<0.03) and high (>75%) (p<0.04) SjO2 values.

Discussion

This study suggests that prolonged high SjO2 is also associated with a bleak long term prognosis. Furthermore, it confirms the association between poor neurological outcome after traumatic brain injury and other secondary physiological insults.

Monitoring of SjO2 was discontinued either at the time that asystole occurred, or after the first set of brain stem tests (four patients). Low SjO2 in those who died gives credence to pathological findings of brain ischaemia7 but death (including brain stem death) did not influence increased SjO2 in group 1 as there was no difference between the dead and the survivors. In previous traumatic brain injury studies admission GCS has been used to categorise patients, but this serves little purpose in practical terms for patients admitted to neurointensive care units, who all require intensive care. The GCS is obscured by necessary emergency treatment out of hospital (intubation and ventilation), and in addition it has been shown to be of low prognostic power in relation to outcome.2 This study therefore included patients with both severe and moderate traumatic brain injury, all of whom required ventilation, and in whom the ISS was no different between patients with poor and good outcomes.

Validated insult data expressed as a percentage of validated monitoring time allows statistical comparison between patients. It reflects the duration of insult perhaps more appropriately than other studies where a single insult was registered when the SjO2 was outside normal values for a designated period of time, but with no consideration given to the duration of insult.6 11-14 In addition, the SjO2 equipment used in this study allowed objective validation because of the signal quality indicator.

Normal values for SjO2 have been deduced from clinical observation of patients with traumatic brain injury,6 11 15 clinical evidence of cerebral dysfunction during carotid surgery,16 and derived values from healthy volunteers in the 1940s by Kety and Schmidt.17 In their landmark paper on determination of cerebral blood flow they included measurements of difference in cerebral arteriovenous oxygen content. From these data normal values were deduced for SjO2 and have subsequently been used by other groups to assess physiological derangement.18 Different methods for defining normality have caused controversy as to the exact lower limit of normal SjO2 with some authors assuming 50%6 11 and others 54%.3 12 13 15 In fact, neither are incorrect as shown in a recent paper comparing SjO2 monitoring with brain tissue oxygenation (PtiO2)19 where SjO2 values of 50%-54% correspond to PtiO2values of about 8.5 to 11 mm Hg (but with a large standard deviation).

A recent retrospective study by Cormio et al 13 concurs with this report. They divided patients into groups with increased, normal, or decreased SjO2 determined by each patient's average SjO2(sampled intermittently). They demonstrated GOS 1 to 3 at 6 months in about 75% (n=260) of patients who had predominantly increased SjO2 values. Although this study may be criticised for using intermittent sampling (at least every 24 hours), it provided evidence that increased SjO2 was associated with variable cerebral blood flow (6.7–195 ml/100 g/m). They also found that increased SjO2 was associated with CPP greater than 70 mm Hg, and a low cerebral metabolic rate for oxygen (CMRO2). Heterogeneous physiology associated with increased SjO2 has also been shown in a study of 50 patients with traumatic brain injury14 where 49 had increased SjO2 at least once during admission and 25% of the desaturation episodes (decreased SjO2) could not be explained by increased PaCO2, ICP, or decreased CPP. There were no outcome data published for these patients.

Our study population was similar in age and severity of injury to other reports,6 11 13 20 but the mortality was lower (21% at 12 months v 36%11 and 31%6 at 3 months). Monitoring time for SjO2also compared favourably, the mean duration of validated monitoring time was 3628 minutes, equivalent to 2.4 days/patient (or about 4.4 days of total monitoring time as only 56% of data were valid3). A prerequisite for an insult to be registered was a minimum of 5 minutes, less than in other work where 106 12 to 1511 minutes was required. A 5 minute threshold may be more sensitive at recording significant injury as it has been shown in animal studies that multiple short episodes of ischaemic conditions cause more brain injury than longer periods with the same total ischaemic duration21-23

There are several plausible explanations for our findings. Inflammation may reduce the ability of neurons to utilise oxygen. McKeating and Andrews24 found intrinsic brain inflammation with a net production of interleukin-6 by the brain after traumatic brain injury. Also, microvascular shunting (exacerbated by neutropil plugging due to adhesion25 as a consequence of inflammatory processes) may be occurring in the brain. These hypotheses would explain the low CMRO2 described by Cormio et al.13 Hyperaemia is an alternative explanation although the associated rise in ICP was treated according to our protocol—that is, initially by hyperventilation—which would result in a reduced blood flow and SjO2. Cormioet al 13 showed that reduced cerebral blood flow was more commonly associated with increased SjO2.

SjO2 gives warning of global cerebral hypoperfusion (SjO2 <54%), cerebral hyperaemia, or non-utilisation of oxygen by brain tissue (SjO2 >75%), and allows therapeutic interventions to be assessed. Continuous monitoring of SjO2 has been possible for several years with the introduction and validation of fibreoptic catheters8 11 26-28 and is superior to intermittent sampling, which can miss discrete events). The physiology of traumatic brain injury is complex and incompletely understood and no single intervention would seem to be a panacea for high SjO2 given that the cerebral blood flow may be high, low, or normal13and CMRO2 variable. But given that aggressive attempts to normalise physiology (and therefore minimise presumed secondary insults) is the mainstay of current therapy for traumatic brain injury, more effort should be made to elucidate the pathophysiology of high SjO2. Only then will rational therapy be applied.

Acknowledgments

We thank PA Jones, EG McKeating, and MJ Souter, for their parts in data collection; T Howells for software development and nursing staff in our neurointensive care unit for their assistance and patience. CM and VE were supported by grants from the Medical Research Council G9508752 and G9301951. These data have been presented, in part, to the Neuroanaesthesia Society of Great Britain in Sheffield, April 1998. We have no conflicts of interest.

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