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J Neurol Neurosurg Psychiatry 70:390-393 doi:10.1136/jnnp.70.3.390
  • Short report

Assessing the risk of early multiple sclerosis in patients with clinically isolated syndromes: the role of a follow up MRI

Early MR findings in 68 patients with clinically isolated syndromes of whom 18 developed multiple sclerosis (MS)1-150 within 1 year

MRI index Cut off
point
Prevalence
n (%)
MS
n
PPV
%
Sensitivity
%
Specificity
%
Baseline MRI:
 Lesions on T2 weighted imaging 1 48 (71) 16 33 89 36
4 37 (54) 14 38 78 54
9 25 (37) 11 44 61 72
 Contrast enhancing lesions 1 21 (31) 11 52 61 80
Baseline and follow up MRI:
 Lesions on T2 weighted imaging at baseline and new lesions at follow up 1 27 (40) 15 55 83 76
 Contrast enhancing lesions at baseline and new contrast enhancing lesions at follow up 1 10 (15) 7 70 39 94
  • 1-150 Clinically probable or definite MS.

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