Zeta class glutathione transferase polymorphisms and Parkinson's disease
- John Curtin School of Medical Research, Australian National University, ACT 2601, Australia
- Department of Medicine, University of Queensland, Australia
- Canberra Clinical School, University of Sydney, Australia
- Professor P G Board
- John Curtin School of Medical Research, Australian National University, ACT 2601, Australia
- Department of Medicine, University of Queensland, Australia
- Canberra Clinical School, University of Sydney, Australia
- Professor P G Board
- John Curtin School of Medical Research, Australian National University, ACT 2601, Australia
- Department of Medicine, University of Queensland, Australia
- Canberra Clinical School, University of Sydney, Australia
- Professor P G Board
Glutathione transferase genes (GST) are candidate genes for Parkinson's disease because they are involved with the metabolism of pesticides, dopamine, and glutathione. Recent reports have suggested an association between Parkinson's disease and polymorphisms of GSTP1 1 orGSTM1 andGSTT1.2
Recently we discovered a new polymorphic site in the zeta class G→T (GSTZ1) gene.3 This consists of a C6T transition at nucleotide 245 in exon 5 that results in an amino acid change at position 82 from methionine to threonine. The T substitution occurs in 14% of white people. We have previously reported two other polymorphic sites at nucleotides 94 and 124 in exon 3.4 There are now thought to be four alleles of GSTZ1:Z1*A(A94A124C245),Z1*B(A94G124C245),Z1*C(G94G124C245,) andZ1*D(G94G …
