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J Neurol Neurosurg Psychiatry 2001;70:784-786 doi:10.1136/jnnp.70.6.784
  • Short report

Increased plasma neurotensin concentrations in patients with Parkinson's disease

  1. R-M Schimpffa,c,
  2. C Avarda,
  3. G Fénelond,
  4. A-M Lhiaubeta,
  5. L Tennezéa,
  6. M Vidailhetb,
  7. W Rostènea
  1. aINSERM U 339, Hôpital Saint Antoine, 184 rue du Faubourg, St Antoine, 75012 Paris, France, bService de Neurologie, cINSERM U 515, dService de Neurologie Hôpital Tenon, 75020 Paris, France
  1. Dr W Rostenerostene{at}adr.st-antoine.inserm.fr
  • Received 13 July 2000
  • Revised 13 December 2000
  • Accepted 5 January 2001

Abstract

Plasma neurotensin (NT) was measured by radioimmunoassay in propanol extracted and unextracted plasma from 16 parkinsonian patients (four before treatment) and 16 age and sex matched controls. Mean plasma NT concentrations were consistently higher in parkinsonian patients than in controls and higher in the four untreated patients than in levodopa treated patients suggesting that plasma NT measurement may represent an easy detectable additional index in diagnosing parkinsonism and provides a novel approach to research in this field.

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