Table 1
Chronic anticonvulsant toxicity with antiepileptic drug treatment
|
Nervous system
|
| Memory and cognitive impairment, hyperactivity and behaviour disturbances, pseudodementia, cerebellar atrophy, peripheral neuropathy |
| Ocular |
| Retinopathy |
| Skin |
| Acne, hirsutism, alopecia, chloasma |
| Liver |
| Enzyme induction |
| Blood |
| Megaloblastic anaemia, thrombocytopenia, pseudolymphoma |
| Immune system |
| IgA deficiency, drug induced systemic lupus erythematosus |
| Endocrine system |
| Decreased thyroxine concentrations, increased cortisol and sex hormone metabolism |
| Bone |
| Osteomalacia |
| Connective tissue |
| Gingival hypertrophy, coarsened facial features, Dupuytren's contracture |
