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Range of cross reactivity of anti-GM1 IgG antibody in Guillain-Barré syndrome
  1. M Koga,
  2. M Tatsumoto,
  3. N Yuki,
  4. K Hirata
  1. From the Department of Neurology, Dokkyo University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321–0293, Japan
  1. Dr N Yukiyuki{at}dokkyomed.ac.jp

Abstract

The cross reactivity of anti-GM1 IgG antibody with various gangliosides and asialo-GM1 in serum samples from 27 patients with Guillain-Barré syndrome was investigated. An enzyme linked immunosorbent assay (ELISA) absorption study showed that anti-GM1 IgG antibody cross reacted with asialo-GM1 in 52% of the patients, GM1b in 41%, GD1b in 22%, and GalNAc-GD1a in 19%, and that it did not cross react with GM2, GT1b, or GQ1b. The antibody that cross reacted with GD1b was associated with a high frequency of cranial nerve involvement and negative Campylobacter jejuni serology. Anti-GM1 IgG antibody has a broad range of cross reactivity which may contribute to various clinical variations of Guillain-Barré syndrome.

  • Guillain-Barré syndrome
  • anti-GM1 antibody
  • cross reactivity

https://doi.org/10.1136/jnnp.71.1.123

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