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J Neurol Neurosurg Psychiatry 71:538-541 doi:10.1136/jnnp.71.4.538
  • Short report

Relapsing intracranial Rosai-Dorfman disease

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Figure 2
Figure 2

Histology from patient 2. (A) Sheets of histiocytic cells with large vesicular nuclei, some with nuclear indentations, are seen. There is an associated infiltrate of polymorphs and lymphocytes. Lymphophagocytosis (emperiopolesis) by the histiocytic cells is clearly seen (haematoxylin and eosin, original magnification×375). (B) The histiocytic cells show strong nuclear and cytoplasmatic staining with S100 protein and lymphophagocytosis is also seen (S100 immunohistochemistry, original magnification×625).

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