Quantitative anal sphincter EMG in multisystem atrophy and 100 controls
- aDepartment of Neurology, Wolfson Medical Center, Holon 58100, Israel, bDepartment of Neurology, Tel Aviv Sourasky Medical Center, Israel, cSackler Faculty of Medicine, Tel Aviv University, Israel
- Dr R Giladgilad-ar{at}inter.net.il
- Received 5 October 2000
- Revised 1 May 2001
- Accepted 10 March 2001
Abstract
OBJECTIVE To evaluate data of quantitative anal sphincter EMG in normal controls and to compare them with patients with multiple system atrophy (MSA).
METHODS Quantitative anal sphincter EMG were performed on 100 normal controls and 11 patients with MSA to characterise EMG data in these two groups.
RESULTS In the normal controls, there was a trend for increased motor unit potential (MUP) amplitude, duration, area, and polyphasicity with advancing age. Patients with MSA exhibited similar MUP size and fibre density. Significant differences were found only in parameters of the recruitment pattern, which were reduced in MSA, with a diminution in the number of active MUPs during rest.
CONCLUSIONS These results may reflect either decreased number of motor cells in Onuf's nucleus without significant consequential reinnervation, or upper motor neuron involvement affecting the anal sphincter in MSA. They further underline the importance of comparative data for age matched controls.
