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J Neurol Neurosurg Psychiatry 71:818-819 doi:10.1136/jnnp.71.6.818a
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Relation between the high production related allele of the interferon-γ (IFN-γ) gene and age at onset of idiopathic Parkinson's disease in Japan

Table 1

IFN-γ allele and carriership frequencies in patients with Parkinson's disease (PD) and in healthy controls as well as in patient subgroups whose ages of onset are early (<50 y) and late (⩾50 y)

PD n (%) Control n (%) Early onset PD n (%) Late onset PD n (%)
Allele (bp):
 116 1 (0.3) 1 (1)
 118 2 (0.6) 1 (0.3) 2 (0.8)
 120 52 (15.3) 41 (13.1) 23 (23) 29 (12.1)
 122 157 (46.2) 143 (45.5) 35 (35) 122 (50.8)
 124 19 (5.6) 16 (5.1) 8 (8) 11 (4.6)
 126 93 (27.4) 92 (29.3) 28 (28) 65 (27.1)
 128 9 (2.6) 8 (2.5) 1 (1) 8 (3.3)
 130 1 (0.3) 1 (0.3) 1 (1)
 132 6 (1.8) 12 (3.8) 3 (3) 3 (1.3)
Total 340 314 100 240
Carriership:
 122 carrier 117 (68.8) 109 (69.4) 28 (56) 89 (74.2)
 122 non-carrier 53 (31.2) 48 (30.6) 22 (44) 31 (25.8)
Total 170 157 50 120
  • For combined alleles 116, 118, 130, and 132, allele frequency: early onset PD v late onset PD χ2=14.3, df=5, Pc=0.028.

  • Carriership frequency: early onset PD v late onset PD χ2=4.62, df=1, Pc=0.039.

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