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Mexiletine is effective on segmental hyperhidrosis: report of two cases
  1. S Ishibashi1,
  2. T Yokota1,
  3. A Inaba1,
  4. M Yamada1,
  5. H Mizusawa1,
  6. T Iwai2,
  7. T Shiojiri3
  1. 1Department of Neurology, Tokyo Medical and Dental University School of Medicine, 1–5–45, Yushima, Bunkyo-ku, Tokyo 113–8519, Japan
  2. 2Department of Surgery, Division of Vascular Surgery
  3. 3Department of Neurology, Asahi General Hospital, I- 1326, Asahi, Chiba, 289-2511, Japan
  1. Correspondence to:
 Dr T Yokota;
 tak-yokota.neuro{at}tmd.ac.jp

https://doi.org/10.1136/jnnp.72.1.122

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    Segmental hyperhidrosis occurs in patients who have spinal cord lesions such as syringomyelia,1 vascular disorders, or tumours. Severe segmental hyperhidrosis not only causes discomfort, but may disturb daily life, as it did with our patients. There have been no reports on the treatment of segmental hyperhidrosis. We report on two patients with segmental hyperhidrosis caused by syringomyelia and cavernous haemangioma of the spinal cord, in which oral administration of mexiletine ameliorated the symptoms.

    A 41 year old woman experienced dysaesthesia of the left side of the trunk, which gradually progressed. At the age of 56 she developed dysaesthesia of the left upper limb as well. At that time, she had excessive sweating on the left side of her face, trunk, and upper limb, even when it was not hot, and had to change her nightwear a few times each night. Neurological examination detected dissociated sensory disturbance in the left half of the trunk in the Th2-Th4 area. Hyperhidrosis was present on the left side from the face to the trunk at the Th7 level. Deep tendon reflexes were …

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