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J Neurol Neurosurg Psychiatry 2002;72:152-161 doi:10.1136/jnnp.72.2.152
  • Advances in neuropsychiatry

Protein aggregates and dementia: is there a common toxicity?

  1. S Lovestone,
  2. D M McLoughlin
  1. Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
  1. Correspondence to:
 Professor S Lovestone, Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK;
 s.lovestone{at}iop.kcl.ac.uk
  • Received 26 January 2001
  • Accepted 27 June 2001
  • Revised 30 May 2001

Abstract

This review considers some of the recent advances made in the understanding of the pathogenic proteins known to aggregate and be implicated in neurodegenerative dementing disorders. It concentrates on the two most obvious candidates for the role of toxic protein in Alzheimer's disease (AD)—β-amyloid peptide and tau—but also considers other proteins in this disorder and in less common but equally devastating diseases.

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