J Neurol Neurosurg Psychiatry 72:403-405 doi:10.1136/jnnp.72.3.403
  • Short report

The Gerstmann syndrome in Alzheimer's disease

  1. E M Wingard1,
  2. A M Barrett2,
  3. G P Crucian3,
  4. L Doty3,
  5. K M Heilman3,4
  1. 1Division of Neurology, Department of Medicine, University of Massachusetts, USA
  2. 2Department of Neurology, Penn State College of Medicine, USA
  3. 3Department of Neurology, University of Florida College of Medicine, Gainesville, FL32610, USA
  4. 4Neurology Service, Veterans Affairs Medical Center, Gainesville, FL, USA
  1. Correspondence to:
 Dr K M Heilman, PO Box 100236, Gainesville, FL32610–0236, USA;
  • Received 8 May 2001
  • Accepted 5 November 2001
  • Revised 20 August 2001


Background: It remains unclear from lesion studies whether the four signs of the Gerstmann syndrome (finger agnosia, acalculia, agraphia, and right-left confusion) cluster because the neuronal nets that mediate these activities have anatomical proximity, or because these four functions share a common network. If there is a common network, with degeneration, as may occur in Alzheimer's disease, each of the signs associated with Gerstmann's syndrome should correlate with the other three signs more closely than they correlate with other cognitive deficits.

Methods: Thirty eight patients with probable Alzheimer's disease were included in a retrospective analysis of neuropsychological functions.

Results: The four Gerstmann's syndrome signs did not cluster together. Finger naming and calculations were not significantly correlated. Right-left knowledge and calculations also did not correlate.

Conclusions: The four cognitive functions impaired in Gerstmann's syndrome do not share a common neuronal network, and their co-occurrence with dominant parietal lobe injuries may be related to the anatomical proximity of the different networks mediating these functions.


    Visit the full archive of podcasts for JNNP here >>

    Free sample
    This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JNNP.
    View free sample issue >>

    Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

    Navigate This Article