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J Neurol Neurosurg Psychiatry 2002;72:564 doi:10.1136/jnnp.72.5.564
  • Magnetic resonance imaging
  • Editorial commentary

“Sick” MRI syndrome

  1. M J Kushner
  1. Eastern Carolina University School of Medicine and the Wilson Neurology Center, Wilson, North Carolina, USA

      At this time, MRI is a better indicator of tissue outcome rather than clinical destiny

      The report by Marx et al (this issue, pp572–575)1 joins the ever growing literature dealing with multiparametric MRI studies of tissue characteristics in stroke. Markers of ischaemic perturbations of cell homoeostasis and perfusion, including changes in diffusion and perfusion weighted imaging (DWI and PWI), seem now to allow human stroke studies more analogous to animal models. Although debate rages, current optimism maintains that MRI delineates the three main tissue compartments in ischaemia. Conceptually these compartments are (a) irreversibly damaged tissue, (b) minimally disrupted tissue destined for eventual recovery, and (c) the “penumbra” …

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