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J Neurol Neurosurg Psychiatry 2002;72:567-571 doi:10.1136/jnnp.72.5.567
  • Review

Benefits and risks of folic acid to the nervous system

  1. E H Reynolds
  1. Correspondence to:
 Dr E H Reynolds, Institute of Epileptology, Weston Education Centre, King's College Denmark Hill Campus, Cutcombe Road, London SE5 9PJ, UK
  • Received 6 August 2001
  • Accepted 29 November 2001
  • Revised 28 November 2001

Abstract

During three decades of neurological practice I have witnessed a remarkable change in attitudes to the benefits and risks of folic acid therapy in nervous system disorders. In the 1960s all that was known and taught was that folic acid was harmful to the nervous system, especially in precipitating or exacerbating the neurological complications of vitamin B12 deficiency. So deeply held was this view that the possibility of neuropsychological benefits from this vitamin was initially viewed with considerable scepticism.1

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