Article Text
Short report
Creutzfeldt-Jakob disease 38 years after diagnostic use of human growth hormone
Abstract
A 47 year old man is described who developed pathology proven Creutzfeldt-Jakob disease (CJD) 38 years after receiving a low dose of human derived growth hormone (hGH) as part of a diagnostic procedure. The patient presented with a cerebellar syndrome, which is compatible with iatrogenic CJD. This is the longest incubation period described so far for iatrogenic CJD. Furthermore, this is the first report of CJD after diagnostic use of hGH. Since the patient was one of the first in the world to receive hGH, other cases of iatrogenic CJD can be expected in the coming years.
- Creutzfeldt-Jakob disease
- iatrogenic disease
- human growth hormone
- incubation period
- CJD, Creutzfeldt-Jakob disease
- EEG, electroencephalographic
- hGH, human growth hormone
Statistics from Altmetric.com
Footnotes
-
↵* Also the Department of Neurology, St Elisabeth Hospital
-
Competing interests: none declared