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The optimum time frame for imaging embolic infarcts for stigmata of haemorrhagic transformation should have merited discussion under the heading “special clinical circumstances”,1 not least because of conflicting evidence about the benefits versus risks of early anticoagulation in the context of unpredictable evolution of embolic infarcts with or without anticoagulant treatment. In a study comprising 30 patients with cardiogenic cerebral embolism, three patients with an initially non-haemorrhagic cerebral infarct, visualised by computed tomography within 12 hours of stroke onset, showed asymptomatic haemorrhagic transformation in the absence of anticoagulant treatment 2–8 days later. One other patient in this subgroup did, however, …