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J Neurol Neurosurg Psychiatry 73:148-153 doi:10.1136/jnnp.73.2.148
  • Paper

Differential effects of three interferon betas on neutralising antibodies in patients with multiple sclerosis: a follow up study in an independent laboratory

Table 3

Incidence (Inc) and prevalence (Prev) of NABs (titre ≥1:5) in patients with multiple sclerosis treated with interferon beta

Betaferon Avonex Rebif
All NAB+ (%) Persistent NAB+ (%) All NAB+ (%) Persistent NAB+ (%) All NAB+ (%) Persistent NAB+ (%)
Months n Inc Prev Inc Prev n Inc Prev Inc Prev n Inc Prev Inc Prev
0 29 0 0 0 0 44 0 0 0 0 36 0 0 0 0
0–3 29 0 0 0 0 44 0 0 0 0 36 2.8 2.8 0 0
3–6 29 24.1 24.1 0 0 44 6.8 6.8 0 0 36 17.1 16.7 2.8 2.8
6–9 26 26.3 38.4 19.2 19.2 39 2.8 5.1 2.6 2.6 29 13.6 20.7 7.1 6.9
9–12 24 16.7 50.0 21.0 37.5 36 3.1 5.5 0 2.8 26 12.5 30.8 8.7 15.4
12–15 22 12.5 59.0 7.7 40.9 30 4.0 6.7 0 3.3 22 20 40.9 0 18.2
15–18 19 25.0 63.1 0 36.8 25 0 8.0 0 4.0 16 50 50.0 0 18.7

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