J Neurol Neurosurg Psychiatry 73:320-323 doi:10.1136/jnnp.73.3.320
  • Short report

Expression of chemokines in cerebrospinal fluid and serum of patients with chronic inflammatory demyelinating polyneuropathy

  1. D J Mahad1,
  2. S J L Howell2,
  3. M N Woodroofe1
  1. 1Biomedical Research Centre, Sheffield Hallam University, Sheffield, UK
  2. 2Department of Neurology, Royal Hallamshire Hospital, Sheffield
  1. Correspondence to:
 Professor M N Woodroofe, Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield S1 1WB, UK;
  • Received 28 January 2002
  • Accepted 7 May 2002
  • Revised 7 May 2002


Chemokines are likely to contribute to the pathogenesis of chronic inflammatory demyelinating polyneuropathy (CIDP), as evidenced by data from experimental autoimmune neuritis. The α and β chemokines in the cerebrospinal fluid (CSF) and serum from patients with CIDP were analysed using an enzyme linked immunosorbent assay. CXCL9, CXCL10, and CCL3 were raised in the CSF in CIDP compared with controls and non-demyelinating neuropathies (p < 0.001). Although the CSF levels of CCL2 were significantly higher than the serum levels for all groups, the difference between groups was not significant. CXCL9, CXCL10, and CCL3 may contribute to the pathogenesis of CIDP by recruiting inflammatory T cells and monocytes to spinal nerve roots, while CCL2 is likely to play a physiological role.


    Visit the full archive of podcasts for JNNP here >>

    Free sample
    This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JNNP.
    View free sample issue >>

    Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

    Navigate This Article