J Neurol Neurosurg Psychiatry 73:350 doi:10.1136/jnnp.73.3.350
  • Letter

Meta-analysis of α synuclein/ NACP polymorphism in Parkinson's disease in Japan

  1. I Mizuta,
  2. M Nishimura*,
  3. E Mizuta,
  4. S Yamasaki,
  5. M Ohta**,
  6. S Kuno
  1. Clinical Research Centre, Utano National Hospital, Kyoto 616-8255, Japan
  1. Correspondence to:
 Dr S Kuno, Clinical Research Centre, Utano National Hospital, Kyoto 616-8255, Japan;

    α Synuclein is a presynaptic protein highly and broadly expressed in the brain but its normal function is unknown.1 The protein is also termed non-amyloid β component precursor (NACP) because of its localisation in amyloid plaques of Alzheimer's disease.1 However, subsequent studies failed to confirm α synuclein as a component of the amyloid plaque.1 α Synuclein/NACP is now known to be a major component of Lewy bodies in Parkinson's disease (PD).1 Point mutations of the α synuclein gene found in three independent PD families suggest that α synuclein may participate in the aetiology of sporadic PD.1 To address this possibility, several groups reported case-control studies using a dinucleotide repeat polymorphism in the promoter region of the gene.2 The previous Japanese study by Izumi et al3 found a tendency of a lower frequency of allele 1 in Japanese PD patients …