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  • Demyelination in the brain as a paraneoplastic disorder: candidates include some cases of seminoma and central nervous system lymphoma

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Demyelination in the brain as a paraneoplastic disorder: candidates include some cases of seminoma and central nervous system lymphoma
  1. J H Jaster1,
  2. F C Dohan, Jr2,
  3. T F O'Brien3
  1. 1Delta Medical Center, 1905 Harbert Avenue, Memphis, Tennessee 38104, USA
  2. 2Division of Neuropathology, Department of Pathology, University of Tennessee, Memphis, Memphis, Tennessee 38163, USA
  3. 3Department of Pathology, Methodist University Hospital, 1265 Union Avenue, Memphis, Tennessee 38104, USA
  1. Correspondence to:
 Dr J H Jaster, Department of Medicine, University of Tennessee, 1905 Harbert Avenue, Memphis, Tennessee 38104, USA;
 harbert38104{at}yahoo.com

https://doi.org/10.1136/jnnp.73.3.352

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    We read with interest the report of Ayuso-Peralta et al,1 which describes a 58 year old woman who presented with several neurological symptoms. Brain imaging was consistent with leukoencephalopathy, and analysis of blood and cerebral spinal fluid was unrevealing. A few months later the patient experienced further neurological deterioration and an open brain biopsy showed central nervous system (CNS) lymphoma, together with diffuse demyelination.

    The authors observed that the presentation of cerebral lymphoma …

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      BMJ Publishing Group Ltd
      Journal of Neurology, Neurosurgery & Psychiatry 2003; 74 142-142 Published Online First: 01 Jan 2003. doi: 10.1136/jnnp.74.1.142-b