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Letter
Hyperthyroidism with increased factor VIII procoagulant protein as a predisposing factor for cerebral venous thrombosis
  1. J Maes1,
  2. A Michotte1,
  3. B Velkeniers2,
  4. T Stadnik3,
  5. K Jochmans4
  1. 1Department of Neurology, Academisch Ziekenhuis, Vrije Universiteit Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
  2. 2Department of Internal Medicine, Division of Endocrinology, Academisch Ziekenhuis, Vrije Universiteit Brussels
  3. 3Department of Radiology and Medical Imaging, Academisch Ziekenhuis, Vrije Universiteit Brussels
  4. 4Department of Clinical Biology, Division of Haematology, Academisch Ziekenhuis, Vrije Universiteit Brussels
  1. Correspondence to:
 Dr J Maes;
 maesjen{at}belgacom.net

https://doi.org/10.1136/jnnp.73.4.458

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    Cerebral venous thrombosis (CVT) is a rare disorder, with an incidence of approximately 4/1 000 000 per year, occurring more frequently in women than in men (ratio of 1.29:1).1 CVT is a multifactorial condition, known predisposing factors include venous stasis, hypercoagulability, vasculitis, systemic lupus erythematosus, and trauma. Mortality after CVT ranges from 5% to 30%.1 The optimal treatment consists of anticoagulation for six months and should only be maintained beyond this time if known risk factors for CVT persist. Treatment should not be discontinued in case of an asymptomatic haemorrhagic transformation of the associated venous infarct.2

    In recent years, a few thyrotoxic patients with CVT have been reported. An association between hyperthyroidism and increase of FVIII has also been described,3 and recent data suggest an increased incidence of venous thrombosis in patients with hyperthyroidism and high FVIII levels.4 Here we report a patient with increased FVIII levels and an autoimmune hyperthyroidism, who developed a CVT complicated by venous infarction.

    Case report

    A 39 year old woman was admitted to the emergency room after …

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    Footnotes

    • Competing interests: none declared