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The incidence of stroke caused by subarachnoid haemorrhage (SAH) remains constant, with intracranial aneurysm rupture causing SAH in up to 5000 patients in the UK per annum. Although this represents less than 5% of all strokes, recognition is of crucial importance since intervention can radically alter outcome. The combined mortality and morbidity for aneurysm rupture reaches 50%; since the condition can affect individuals at any age, long term morbidity in survivors can be substantial.1 Failure to diagnose SAH exposes a patient to the fatal effects of a further bleed, and also to complications which can now be avoided or successfully treated.2,3
▸ PATHOLOGY
SAH refers to a leakage of blood into the subarachnoid spaces (fig 1A) which is a continuous space between the supratentorial and infratentorial compartments. A greater concentration of blood products around the site of the bleed is usual, but SAH originating from a focal source can be more diffuse and spread throughout wider aspects of the subarachnoid space. Haemorrhage can extend into adjacent parenchymal structures (fig 1B) and ventricular system, with associated high morbidity and mortality (fig 1C).
Inflammatory processes (table 1), excited by the presence of red cell breakdown products, affect the large vessels of the circle of Willis and smaller vessels within the subpial space.4 These processes are complex, but combine to impair the adequate distribution of blood to affected territories. Cerebral ischaemia, often delayed by several days, is a common occurrence and major source of cerebral injury (fig 2).
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