Article Text
PDFNeuroscience for neurologists
Molecular pathogenesis of neuroinflammation
Abstract
The past few years have seen significant progress towards understanding the mechanisms of immune surveillance and inflammation in the nervous system. In this review, the milestones of scientific discovery in this field are discussed, and the strengths and limitations of the different ways of examining the molecular pathogenesis of neuro-inflammation examined. The review is limited to the inflammatory reactions of the central nervous system that occur in multiple sclerosis and experimental autoimmune encephalomyelitis.
- inflammation
- central nervous system
- immune system
- BDNF, brain derived neurotrophic factor
- EAE, experimental autoimmune encephalitis
- EAN, experimental autoimmune neuritis
- IMDS, isolated monosymptomatic demyelinating syndrome
- INFγ, interferon γ
- MBP, myelin basic protein
- MHC, major histocompatibility complex
- MOG, myelin oligodendrocyte glycoprotein
- PLP, proteolipid protein
- TNFα, tumour necrosis factor α
- CNS, central nervous system
- PCR, polymerase chain reaction