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J Neurol Neurosurg Psychiatry 2003;74:1476-1484 doi:10.1136/jnnp.74.11.1476
  • Review

Human cellular inflammation in the pathology of acute cerebral ischaemia

  1. C J S Price1,
  2. E A Warburton2,
  3. D K Menon3
  1. 1Department of Medicine, Addenbrooke’s Hospital, Cambridge, UK
  2. 2Division of Stroke Medicine, Addenbrooke’s Hospital
  3. 3Anaesthesia, University of Cambridge
  1. Correspondence to:
 Dr Christopher J S Price, Box 83 (R3 Neuroscience), Addenbrooke’s Hospital, Cambridge CB22QQ, UK; 
 cp252medschl.cam.ac.uk
  • Received 19 December 2002
  • Accepted 9 June 2003
  • Revised 23 May 2003

Abstract

Leucocytes form important effector pathways for inflammation. This article reviews the clinical evidence for the presence of a cellular inflammatory response in cerebral ischaemia, and attempts to define its temporal profile and spatial distribution. The processes involved in recruitment and activation of leucocytes in this context are addressed, and the successes and failures of interventions aimed at these processes discussed.

Footnotes

  • Competing interests: none declared

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