Neurogenetics: single gene disorders
- Division of Neurology, Cedars-Sinai Medical Center, Departments of Medicine and Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
- Correspondence to: Dr S-M Pulst 8631 West Third Street, Suite 1145, Los Angeles, CA 90048, USA; pulstcshs.org
Abstract
The advent of molecular biology has changed the way in which neurological illnesses are classified, and the single genes causing a number of disorders have been identified. In addition, techniques such as linkage analysis and DNA sequencing have resulted in greater understanding of multi-gene diseases. This review covers some of the molecular tools and animal models used for genetic analysis and for DNA based diagnosis, and a brief survey of information available on the internet.
