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Diffuse brain oedema in idiopathic intracranial hypertension: a quantitative magnetic resonance imaging study
  1. M E Bastin1,
  2. S Sinha2,
  3. A J Farrall2,
  4. J M Wardlaw2,
  5. I R Whittle2
  1. 1Medical and Radiological Sciences (Medical Physics), University of Edinburgh, Edinburgh, UK
  2. 2Clinical Neurosciences, University of Edinburgh
  1. Correspondence to:
 Dr Mark Bastin
 Medical and Radiological Sciences (Medical Physics), University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK; mebskull.dcn.ed.ac.uk

Abstract

Objectives: To investigate the hypothesis that idiopathic intracranial hypertension is associated with diffuse brain oedema, using quantitative magnetic resonance imaging.

Methods: Values for the mean diffusivity of water (<D>) and the proton longitudinal relaxation time (T1) were measured for various brain regions in 10 patients with idiopathic intracranial hypertension and 10 age, sex, and weight matched controls.

Results: No significant differences in <D> and T1 values were found between patient and control groups in any of the brain regions investigated.

Conclusions: The results suggest that idiopathic intracranial hypertension is not associated with abnormalities of convective transependymal water flow leading to diffuse brain oedema.

  • idiopathic intracranial hypertension
  • magnetic resonance imaging
  • diffusion
  • proton longitudinal relaxation time
  • ADC, apparent diffusion coefficient
  • DW-MRI, diffusion weighted magnetic resonance imaging
  • EP, echo planar
  • IIH, idiopathic intracranial hypertension
  • IR, inversion recovery
  • ROI, region of interest
  • TI, inversion time

https://doi.org/10.1136/jnnp.74.12.1693

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    Footnotes

    • Competing interests: none declared