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Georges Marinescu (1864–1938)
  1. L F Haas

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Marinescu was Romanian and a pupil of Charcot, who became professor of neurology in Bucharest. He contributed knowledge to the anatomy and pathology of the nervous system. He coined the term chromatolysis and studied the effects of hypophysectomy, and observed the fatal effects of removal of the pituitary gland in animals. Alzheimer described neurofibrillary tangles and sclerotic plaques found in Alzheimer’s disease in 1906 and 1907. Earlier in 1892, Georges Marinescu with Paul Blocq had modified the staining techniques for glia (previously developed by Santiago Ramon y Cajal) and observed plaques in the cortices of two senile individuals with gross memory defects, mental confusion, aphasia, and apraxia. With Nicolesco he reported on the clinical aspects of thalamic lesions, and elaborated further on what was already known about the thalamic syndrome. With Blocq, in 1893 he reported a case of Parkinson’s disease associated with a tuberculoma in the substantia nigra. These observations were the basis of Edouard Brissaud’s suggestion in 1894 of the nigral origin of this disorder. Eponymically Marinescu is remembered for the Marinescu-Sjogren syndrome (cataracts, mental retardation, short stature delayed sexual development, and ataxia). Marinescu was honoured philatelically by a stamp issued by Romania in 1962 (Stanley Gibbons no 2943, Scott no 1496).

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