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J Neurol Neurosurg Psychiatry 74:574-576 doi:10.1136/jnnp.74.5.574
  • Paper

Efficacy of methylprednisolone pulse therapy on neuroleptic malignant syndrome in Parkinson’s disease

Table 2

Selected changes after 10 days in the 40 subjects

Percentage change after 10 days follow up (result at 10 days)
Placebo (n=18) Steroid (n=20) p value*
Results expressed as mean ± SD.
*Wilcoxon rank sum test.
Heart rate (beats/min) −4.3±1.9 (80±16) −6.5±2.0 (68±5) 0.0027
Systolic blood pressure (mm Hg) +20.9±18.1 (110±9) +33.4±13.5 (122±7) 0.0114
Diastolic blood pressure (mm Hg) +22.5±19.3 (64±7) +28.7±19.9 (68±5) 0.13
Body temperature (°C) −4.3±1.9 (37.5±0.5) −7.5±2.3 (36.1±0.6) 0.0001
Serum creatine kinase (IU) −83.3±12.2 (631±316) −98.8±1.5 (56±17) <0.0001
White blood cell count (per mm3) −44.2±10.8 (9451±2226) −52.2±15.6 (7339±1946) 0.0326

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