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J Neurol Neurosurg Psychiatry 2003;74:1014 doi:10.1136/jnnp.74.8.1014
  • Mental deterioration after head injury
  • Editorial commentary

Mental deterioration late after head injury—does it happen?

  1. N Brooks
  1. Rehab Without Walls, 27 Presley Way, Crownhill, Milton Keynes MK8 0ES, UK; nbrooks@rww.org.uk

      The relation between cognitive state after a head injury and APOE status is still ambiguous

      The possibility of late mental deterioration after head injury has been raised for many years, although infrequently until recently. It is now becoming quite a hot topic, with three separate and interacting strands of research and ideas. The first of the three interrelated topics is the work on genetic factors in recovery after head injury. The second is the possible relation between head injury and later onset of Alzheimer’s disease. The third is the possible relation between head injury and (much) later cognitive deterioration.

      There is certainly evidence to draw on in …

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