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J Neurol Neurosurg Psychiatry 74:1128-1130 doi:10.1136/jnnp.74.8.1128
  • Short report

Genetic loading in familial migraine with aura

Table 1

Statistical comparison of risk to siblings of probands, and age at onset and aura type of probands stratified by family history of migraine with aura

(A) Risk to siblings (MA siblings (n)/total siblings (n)) Two generation Three generation
    one generation (3/39; 7.8%) NS χ2=9.95, p<0.002
    two generations (7/51; 13.7%) χ2=6.24, p=0.0125
    three generations (19/51; 37.3%)
(B) Mean (SD) age at onset (AO) of MA probands Two generation Three generation
    one generation (26.1 (11.7)) NS F=5.138, p=0.030
    two generation (21.7 (8.7)) NS
    three generation (17.6 (8.1))
(C) Aura type of MA probands (probands with visual aura (n) plus*/ total probands (n)) Two generation Three generation
*Visual aura plus refers to proband report of visual plus one of aphasic, sensory or motor aura; NS, not significant; †no comparison performed; SD, standard deviation.
    one generation (13/19; 68.4%) NS NS
    two generation (11/20; 55.0%) χ2=4.44, p=0.035
    three generation (14/15; 93.3%)

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