Progressive multifocal leucoencephalopathy with unusual inflammatory response during antiretroviral treatment
- 1University of Kiel, Germany
- 2Emory University of Atlanta, USA
- 3Johann Wolfgang v Goethe University, Frankfurt, Germany
- Correspondence to: Dr C Hoffmann, HIV-Ambulance, University of Kiel, Chemnitztrasse 33, Kiel 24116, Germany; c.hoffmann{at}med2.uni-kiel.de
- Received 27 September 2002
- Revised 10 February 2003
Abstract
A case of biopsy verified progressive multifocal leucoencephalopathy (PML) in an HIV patient is presented. Imaging and histological examination confirmed remarkable inflammatory activity accompanied by an unusually benign clinical course despite no clear evidence of immune reconstitution after the start of antiretroviral treatment. This case not only raises several questions regarding the pathophysiology of PML, but gives also evidence that AIDS associated inflammatory PML must be considered another clinical entity in the expanding range of diseases now commonly referred to as the immune reconstitution syndrome.
- PML, progressive multifocal leuconcephalopathy
- JCV, JV virus
- HAART, highly active antiretroviral therapy
