Table 2
Clinical characteristics of APOE ε4 carriers and non-carriers
| No ε4 | 1 or 2 ε4 | p | Correlation with number of ε4 alleles | |
|---|---|---|---|---|
| Data are given as mean (SD). Two way repeated measures analysis of variance with a post hoc Fisher LSD was used to compare APOE ε4 carriers with non-carriers. Spearman rank order was used for correlation analysis. NS, not statistically significant; –, not applicable given negative two way repeated measures analysis of variance. | ||||
| AD | n=223 | n=281 | p<0.002 | |
| Mean age of onset (y) | 76.5 (8.3) | 74.3 (7.8) | P<0.003 | r=−0.199; p<0.0001 |
| Rate of cognitive decline | 6.6 (5.2) | 6.0 (4.5) | NS | NS |
| MMSE score | 13.8 (6.7) | 14.6 (7.0) | NS | NS |
| FTD | n=33 | n=14 | NS | |
| Mean age of onset (y) | 65.3 (11.8) | 66.3 (5.5) | – | NS |
| Rate of cognitive decline | 3.2 (3.5) | 3.5 (2.2) | – | NS |
| MMSE score | 21.5 (6.8) | 19.8 (5.0) | – | NS |
| VaD | n=86 | n=66 | NS | |
| Mean age of onset (y) | 75.1 (10.2) | 74.8 (7.0) | – | NS |
| Rate of cognitive decline | 7.4 (6.9) | 6.2 (5.0) | – | NS |
| MMSE score | 16.6 (7.2) | 16.6 (6.9) | – | NS |
| Mixed dementia | n=67 | n=65 | NS | |
| Mean age of onset (y) | 79.1 (6.8) | 76.9 (5.4) | – | r=−0.218; p=0.017 |
| Rate of cognitive decline | 5.9 (3.8) | 6.5 (4.7) | – | NS |
| MMSE score | 13.0 (6.2) | 13.6 (6.3) | – | NS |
| MCI | n=17 | n=27 | NS | |
| Mean age of onset (y) | 73.5 (9.0) | 69.7 (7.2) | – | r=−0.312; p=0.040 |
| Rate of cognitive decline | 2.0 (2.7) | 2.4 (3.2) | – | NS |
| MMSE score | 24.6 (3.4) | 26.1 (2.8) | – | NS |
| PD | n=21 | n=9 | p=0.014 | |
| Mean age of onset (y) | 69.0 (7.7) | 67.7 (8.3) | NS | NS |
| Rate of cognitive decline | 2.6 (2.3) | 4.0 (3.4) | NS | NS |
| MMSE score | 20.9 (6.3) | 12.7 (7.2) | p=0.006 | r=−0.486; p=0.012 |
| DLB | n=12 | n=5 | NS | |
| Mean age of onset (y) | 72.2 (8.0) | 66.2 (10.0) | – | NS |
| Rate of cognitive decline | 9.0 (10.1) | 6.0 (5.3) | – | NS |
| MMSE score | 16.1 (8.0) | 16.4 (4.2) | – | NS |
| MSA/PSP | n=9 | n=3 | NS | |
| Mean age of onset (y) | 66.0 (9.2) | 67.7 (4.7) | – | NS |
| Rate of cognitive decline | 1.7 (2.3) | 4.0 (3.6) | – | NS |
| MMSE score | 24.8 (6.7) | 17.0 (15.1) | – | NS |
