Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in amyotrophic lateral sclerosis

Table 1

Patient characteristics for age, sex, disease duration, ALS functional rating scale, and disease rate. Clinical examination findings divided patients into those with predominantly upper motor neuron (umn), lower motor neuron (lmn), and mixed signs. One patient with some missing clinical data was not entered into the correlation analyses between FA, MD, and clinical markers. Median values with ranges (in parentheses) are shown at the bottom of the table

Subject	Age (y)	Sex	Disease duration (months)	ALS Functional Rating Scale	Disease rate (ALS units/month)	Predominant clinical signs
Patients	65	male	36	31	0.25	umn
	51	male	84	34	0.07	umn
	66	female	14	30	0.71	mixed
	58	male	36			mixed
	60	female	15	26	0.93	mixed
	71	male	42	22	0.43	mixed
	55	female	22	25	0.68	mixed
	42	male	12	32	0.67	umn
	53	male	48	32	0.17	mixed
	67	female	27	23	0.63	lmn
Patients	56	male	17	32	0.47	mixed
	51	male	11	28	1.09	mixed
	63	male	60	28	0.20	umn
	70	female	12	31	0.75	mixed
	46	male	7	18	3.14	mixed
	63	male	24	27	0.54	lmn
	59	male	24	37	0.13	mixed
	28	male	14	23	1.21	mixed
	59	male	18	30	0.56	mixed
	57	male	54	31	0.17	mixed
	54	male	23	27	0.57	mixed
Patient group	58.0	16M:5F	23	28	0.55	4 umn
	(28–71)		(7–84)	(11–37)	(0.07–1.21)	15 mixed
					excludes outlier	2 lmn
Control group	51.5	9M:5F
	(37–71)

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Diffusion tensor imaging detects corticospinal tract involvement at multiple levels in amyotrophic lateral sclerosis

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