Article Text
Abstract
A 69 year old woman presented with cognitive impairment and supranuclear gaze palsy caused by paraneoplastic limbic/brain stem encephalitis associated with atypical medullary breast carcinoma. The cerebrospinal fluid from the patient harboured an anti-neuronal cell antibody against Ma2 antigen, but not against Ma1 or Ma3 antigen. Despite the antibody being restricted to the Ma2 antigen, the patient’s cancer tissue expressed Ma1, Ma2, and Ma3 mRNAs. These results, and the expression of Ma2 mRNA in an atypical medullar breast carcinoma in another patient without paraneoplastic encephalitis, indicate that the induction of anti-Ma2 antibody depends on host immunoreponsiveness and not on the presence of the antigen itself in the cancer.
- paraneoplastic limbic/brain stem encephalitis
- anti-Ma2 antibody
- breast cancer
- ECD-SPECT
- 99mTc-ethyl-cysteinate dimer single photon emission computed tomography
- FLAIR, fluid attenuated inversion recovery
- GST, glutathione-S-transferase
- mRNA, messenger RNA
- PCR, polymerase chain reaction
- RT-PCR, reverse transcriptase polymerase chain reaction
- SDS-PAGE, sodium dodecyl sulphate polyacrylamide gel electrophoresis
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- ECD-SPECT
- 99mTc-ethyl-cysteinate dimer single photon emission computed tomography
- FLAIR, fluid attenuated inversion recovery
- GST, glutathione-S-transferase
- mRNA, messenger RNA
- PCR, polymerase chain reaction
- RT-PCR, reverse transcriptase polymerase chain reaction
- SDS-PAGE, sodium dodecyl sulphate polyacrylamide gel electrophoresis