Table 2
Clinical features of Down syndrome
| Craniofacial | ▸ Flattened occiput |
| ▸ Large tongue | |
| Ocular | ▸ Oblique palpebral fissures |
| ▸ Median epicanthic folds | |
| ▸ Brushfield spots in the iris | |
| Auditory | ▸ Conductive hearing loss |
| Somatic | ▸ Reduced linear growth |
| ▸ Short incurved fifth finger | |
| ▸ Single palmar crease | |
| ▸ Abnormal dermatoglyphics | |
| Neurological | ▸ Learning difficulty (average IQ 50) |
| ▸ Hypotonia | |
| ▸ Epilepsy (in ∼6%)—especially infantile spasms | |
| ▸ Early onset dementia (in 1/3) | |
| Haematological | ▸ Impaired immune function |
| ▸ Increased risk of leukaemia |
